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Advances in Gene Therapies for Retinal Disorders: Individualized Management of Patients

By: Allen C. Ho, MD, FACS; Robert Avery, MD; Pravin U. Dugel, MD; Jeffrey S. Heier, MD

In Person Credits: 1.5

Introduction and Overview: Where We’ve Come in Gene Therapy by Allen Ho, MD
Ocular Gene Therapy Delivery by Robert Avery, MD
Gene Therapy for Wet AMD: Current Clinical Trials by Jeffrey Heier, MD
Changing Retinal Landscape and Implications for Future Therapies by Pravin Dugel, MD
Case Discussion
Closing Comments and CME posttest by Allen Ho, MD

Expiration Date: Tuesday, December 31, 2019
Release Date: July 27, 2019

Learning Objectives

  • Describe gene therapy and how it may be used in treating retinal disorders.
  • Distinguish between gene addition, gene augmentation, and gene editing.
  • Explain which retinal disorders are likely to benefit from gene therapy.
  • Differentiate the various gene therapy delivery methods and the differences among them.

Accreditation and Designation Statement

Accreditation Statement
Evolve Medical Education LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians

Credit Designation Statement
Evolve Medical Education LLC designates this live activity for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Faculty and Disclosures

Allen C. Ho, MD, FACS
Professor of Ophthalmology
Thomas Jefferson University

Director of Retina Research
Wills Eye Hospital
Philadelphia, PA

Mid Atlantic Retina

Chief Medical Editor, Retina Today

Robert Avery, MD
California Retina Consultants
Santa Barbara, CA

Associate Medical Editor, Retina Today

Pravin U. Dugel, MD
Managing Partner, Retinal Consultants of Arizona
Phoenix

Clinical Associate Professor of Ophthalmology, Doheny Eye Institute, Keck School of Medicine, University of Southern California

Physician Executive Director, Banner Eye Institute
Phoenix, AZ

Founding Partner, Spectra Eye Institute
Sun City, AZ

Retina Today Editorial Board Member

Jeffrey S. Heier, MD
Co-President and Medical Director
Director of the Vitreoretinal Service

Director of Retina Research
Ophthalmic Consultants of Boston

DISCLOSURE POLICY
It is the policy of Evolve that faculty and other individuals who are in the position to control the content of this activity disclose any real or apparent conflict of interests relating to the topics of this educational activity. Evolve has full policies in place that will identify and resolve all conflicts of interest prior to this educational activity.

Robert Avery, MD, and/or spouse/partner has had a financial agreement or affiliation during the past year with the following commercial interests in the form of Consultant: Alimera, Allergan, Amgen, Apellis, Bausch + Lomb, Clearside, Eyepoint, Genentech, Helio, lridex, Notal, Novartis, OcularTheraputix, Regeneron, Replenish, and Santen. Grant Research: Genentech. Shareholder: Alcon, Novartis, Regeneron, and Replenish.

Pravin U. Dugel, MD, has had a financial agreement or affiliation during the past year with the following commercial interests in the form of Consultant/ Advisory Board Member: Abbott/AMO, Acucela, Aerie Pharmaceuticals, Aerpio, Alcon, Alimera Sciences, Allergan, Amgen, Annidis, ArticDX, Avalanche, Bausch + Lomb, Boehringer lngelheim, ByeOnics, Carl Zeiss Meditec, Chengdu Kanghong Biotechnology, Clearside Biomedical, CDR-Life, Inc., Digisight, Dose Medical, Genentech, Graybug Vision, lrenix, Kodiak Sciences, Lutronic, Lux Bioscience, Macusight, NeoVista, Neurotech, Novartis, Oculis, Ophthotech, Omeros, Opthea, Optovue, ORA, Orbis International, Panoptica, Pentavision, pSivida Corporation, QLT, Inc., Regeneron, Roche, Santen, SciFluor Life Sciences, Shire Human Genetics, Spark Therapeutics, Stealth Biotherapeutics, Thrombogenetics, Topcon, and TrueVision. Stock/Shareholder: Aerpio, Alimera, Annidis, ArctixDx, Clearside Biomedical, Digisight, lrenix, Ophthotech and PanOptica.

Jeffrey S. Heier, MD, and/or spouse/partner has had a financial agreement or affiliation during the past year with the following commercial interests in the form of Consultant: 4DMT, Aerie, Aerpio, AKROS, Alkahest, Apellis, Array, Asclepix, Bayer, Biomarin, Beaver Visitec lnt’I, Daiichi, Eloxx, Galecto, Galimedix, Genentech, Generation Bio, Helie, Interface, lrenixx, Janssen, Kala, Kanghong, Kodiak, Notalvision, Novartis, Omeicos, Orbit Bioemedical, Regeneron, RegenXBio, Retrotope, Scifluor, Shire, Stealth BioTherapeutics, Thrombogenics, Voyant, and Zeiss. Grant Research: Aerpio, Apellis, Clearside, Daiichi, Foreseehome, Genentech, Genzyme, Hemera, Janssen, Kalvista, Kanghong, Novartis, Ocudyne, Ophthotech, Optos, Optovue, Regeneron, RegenXBio, and Thrombogenics. Shareholder: Adverum,Aldeyra, Allegro, Digital Surgery Systems, Ocular Therapeutics, and Jcyte.

Allen C. Ho, MD, FACS, and/or spouse/partner has had a financial agreement or affiliation during the past year with the following commercial interests in the form of Consultant: Aerpio, Aerie, Alcon, Allergan, Asclepix, Beaver EndoOptiks, BioTime, Chengdu Kang Hong, Eloxx, Everads, Genentech, Janssen, Notal, Ocugenix, ONL, Optovue, Orbit Biomedical, PanOptica, PRN, ProQR, Regeneron, RegenxBio, Sanofi, and Second Sight. Grant Support: Aerie, AGTC, Alcon, Allergan, Apellis, Chengdu Kang Hong, Genentech, Janssen, NEI/NIH, ProQR, Regeneron, RegenxBio, Sanofi, and Second Sight. Ownership: Covalent, ONL, PanOptica, PRN, and Visionary Ventures.

Editorial Support Disclosures
Erin K. Fletcher, MIT, director of compliance and education; Susan Gallagher-Pecha, director of client services and project management; Cassandra Richards, director of education development, Evolve have no financial relationships with commercial interests. Jaya Kumar, MD, peer reviewer, has had a financial agreement or affiliation during the past year with the following commercial interests in the form of Consultant: Allergan.

 

Disclaimer

Off-Label Statement
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The opinions expressed in the educational activity are those of the faculty. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer
The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of Evolve,  or REGENEXBIO Inc.

Pretest

  • 1 Not at all confident2 Not very confident3 Neutral4 Confident5 Very confident

A digital archive of the presentation will be available online in the coming weeks. Please check back.

Please proceed to the post-test and claim credit page.

Next

Test

Instructions

Step 1 of 2

50%
  • 1 - Not at all confident2 - Not very confident3 - Neutral4 - Confident5 - Very confident
  • AgreeNeutralDisagree
    Describe gene therapy and how it may be used in treating retinal disorders.
    Distinguish between gene inhibition, gene augmentation, and gene editing.
    Explain which retinal disorders are likely to benefit from gene therapy.
    Differentiate the various gene therapy delivery methods and the differences among them.
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