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Integrated Care for the Diabetic Patient – Part 2

By: Mark Dunbar, OD, moderator; A. Paul Chous, OD; Steven G. Ferrucci, OD; Jay M. Haynie, OD; Leo Semes, OD

Supplement Credits: 2

This continuing education (CE) activity captures content from a roundtable discussion held in September 2016.

It remains clear that although diabetes is a systemic disorder, the manifestations of diabetic complications will occur without optimal glycemic and blood pressure control. Optometrists can help continually reinforce that message by educating patients about the necessity for ongoing and yearly dilated eye examinations, and discussing the potential treatments should vision loss become obvious.

Expiration Date: Saturday, February 29, 2020
Release Date: February 2017

Learning Objectives

After successfully completing this activity, optometrists will have improved their ability to:

  • Determine who is a high-risk patient for the onset of diabetic eye disease
  • Discuss the importance of conducting yearly dilated exams on diabetic patients
  • Develop plans to initiate comanagement of the diabetic patient with both ophthalmologists and primary care physicians/endocrinologists
  • Implement strategies to educate patients on the ocular manifestations of diabetes

Accreditation and Designation Statement

This course is COPE approved for 2.0 hours of CE credit for optometrists.

Faculty and Disclosures

Mark Dunbar, OD, has had a financial agreement or affiliation during the past year with the following commercial interests in the form of Consultant/Advisory Board/Speaker’s Bureau: Allergan; Carl Zeiss Meditec; and Regeneron Pharmaceuticals.

A. Paul Chous, OD, has had a financial agreement or affiliation during the past year with the following commercial interests in the form of Consultant/Advisory Board/Speaker’s Bureau: Bausch & Lomb Incorporated; CooperVision; Freedom Meditech; Regeneron Pharmaceuticals; and ZeaVision, LLC. Grant/Research Support: ZeaVision, LLC.

Steven G. Ferrucci, OD, has had a financial agreement or affiliation during the past year with the following commercial interests in the form of Consultant/Advisory Board/Speaker’s Bureau: Alcon; CenterVue; Macula Risk; and Maculogix.

Jay M. Haynie, OD, has had a financial agreement or affiliation during the past year with the following commercial interests in the form of Consultant/Advisory Board/Speaker’s Bureau: ArticDx; Carl Zeiss Meditec; Notal Vision, Ltd.; and Reichert.

Leo Semes, OD, has had a financial agreement or affiliation during the past year with the following commercial interests in the form of Advisory Board/Speaker’s Bureau: Alcon; Allergan; Ametek; Bausch & Lomb Incorporated; Genentech; Maculogix; Optovue; Regeneron Pharmaceuticals; ScienceBased Health; Shire; and ZeaVision LLC. Shareholder: HPO. Stock Options: ZeaVision LLC.

EDITORIAL SUPPORT DISCLOSURE

Cheryl Cavanaugh, MS, director of operations, Evolve Medical Education LLC; and Bryan Bechtel, medical writer,

have no real or apparent conflicts of interest to report. Rishi P. Singh, MD, peer reviewer, has had a financial agreement or affiliation during the past year with the following commercial interests in the form of Consultant/Advisory Board/Speaker’s Bureau: Alcon; Allergan Plc; Carl Zeiss Meditec; Genentech; Optos; Regeneron Pharmaceuticals; and Shire Plc. Grant/ Research Support: Alcon; Apellis Pharmaceuticals; Genentech; and Regeneron Pharmaceuticals.

DISCLOSURE ATTESTATION

Each of the contributing physicians listed above has attested to the following: (1) that the relationships/affiliations noted will not bias or otherwise influence his or her involvement in this activity; (2) that practice recommendations given relevant to the companies with whom he or she has relationships/ affiliations will be supported by the best available evidence or, absent evidence, will be consistent with generally accepted medical practice; and (3) that all reasonable clinical alternatives will be discussed when making practice recommendations.

PRODUCT USAGE IN ACCORDANCE WITH LABELING

Please refer to the official product information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of Evolve Medical Education LLC, The University of Houston, Regeneron Pharmaceuticals, or Advanced Ocular Care.

Pretest

New cases of diabetes are being diagnosed at epidemic proportions. Several factors, including poor dietary habits, declining exercise, and an increase in sedentary activities are contributing to an accelerating rate of new cases. As this public health crisis emerges, it is becoming clear that early diagnosis and treatment can set patients up for more favorable outcomes. This sentiment is true for systemic complications as well as those that affect vision.

A look at the numbers suggests that many patients may be slipping through the cracks. Of the approximately 8 million individuals living with diabetic retinopathy, only about 5.8 million are diagnosed.1-3 Perhaps even more surprising, of the 2.3 million with diabetic macular edema, only about 1.5 million receive a diagnosis,1 and only about 400,000 make it into the retina specialist to receive treatment.3,4 About one in four patients 40 years of age and older with diabetes does not comply with the recommended yearly eye examination, and the number one reason stated is that they “do not see a need” for this step.5 The American Academy of Ophthalmology suggests this number may be as high as 40%.6

These figures confirm that optometrists are more important than ever in helping to manage the volume of patients, because the implications for undiagnosed disease are dire: left unmonitored, patients can quickly lose vision that even the most aggressive treatment will not restore. Moreover, if a patient is losing vision as a consequence of uncontrolled disease, he or she is also at greater risk for systemic complications as a result of uncontrolled disease: every percentage reduction in glycosylated hemoglobin (A1C) reduces the risk of microvascular complications by almost 40%, and for every 10 mm Hg decrease in systolic blood pressure, the risk of diabetes complications drops 12%.7,8

In the pages that follow, the expert panel and I review the emerging evidence regarding early diagnosis and treatment, as well as the criteria for when patients should be referred for treatment. We also discuss the important role optometrists can play in educating patients about their disease.

—Mark Dunbar, OD, moderator


Mark Dunbar, OD: From a historical perspective, what was the importance of the Early Treatment of Diabetic Retinopathy Study (ETDRS), and how did that shape practice patterns and referral guidelines?

Leo Semes, OD: At the time the ETDRS was conducted, it was widely speculated that laser was beneficial for treating diabetic retinopathy (DR), but there were very little published data. The ETDRS investigators sought to evaluate argon laser photocoagulation in the management of patients with nonproliferative DR (NPDR) or early proliferative DR (PDR). The study actually followed the Diabetic Retinopathy Study effort, which concluded that laser helped slow severe vision loss.9-13 The ETDRS had three objectives: (1) to determine when in the course of DR it was most effective to initiate photocoagulation therapy to slow the progression of DR; (2) to determine if focal laser photocoagulation was effective in the treatment of macular edema (ME); and (3) to study if aspirin was effective in altering the course of DR. Although the aspirin question never became significant, there were several important findings from the ETDRS, with implications for both the retinal physician community and for optometrists.

As for treatment, it was shown that early panretinal photocoagulation (PRP) reduced the risk of severe vision loss by about 23%, and early PRP resulted in a significant reduction in the rate of developing high-risk PDR compared with deferral of photocoagulation.14 Using focal laser treatment for ME (specifically, clinically significant ME [CSME]), which was predefined in the ETDRS, reduced the risk of moderate vision loss by at least 50%. The ETDRS established that laser treatment reduces vision loss but also that laser was not good for restoring lost vision: Fewer than 3% of those treated with laser had a greater than 15-letter increase in vision.

For practicing optometrists, the most important point learned from the ETDRS was the criteria for CSME. (See ETDRS Criteria for CSME.) At the time, these definitions were crucial for understanding what was going on in a patient’s eye. Of course, they are also inherently limited, because the clinical examination is not always conducted under ideal conditions. For instance, poor dilation or a cloudy media may obscure the surgeon’s view. And this is why we are fortunate to now have optical coherence tomography (OCT) at our disposal for identifying CSME, which, of course, we call center-involving ME (Figure 1).

Figure

Figure 1. High-definition OCT images show cotton wool spots and macular fluid/thickening consistent with center-involved macular edema (OD; visual acuity measured 20/50 at the time of the image). Note the inversion of foveal contour and compare to the absence of foveal reflex as well obscured central macula on the fundus photo.

Dr. Dunbar: In the era of OCT, what is the potential role of establishing a diagnosis of CSME?

Jay M. Haynie, OD: CSME is still relevant because it is a helpful data point for building a risk profile. We know from studies what happens to untreated patients who have CSME. For those who do not use OCT, CSME is even more important.

Figure

Steven G. Ferrucci, OD: I still teach residents about CSME and how to identify it based on the three definitions. However, the advent of OCT really drove appreciation for whether the edema was affecting the macula. I think it becomes easier with experience to recognize ME, but very mild edema is still extremely difficult to recognize. For that reason, I still think that CSME is important to teach to residents and that it is useful for understanding the complete picture.

A. Paul Chous, OD: How do you define “center involved”? Does it have to be in the foveal center?

Dr. Ferrucci: I interpret “center involved” to mean that the ME is actually in the fovea.

Dr. Chous: I agree, and I use those criteria in my clinic as well.

Dr. Haynie: OCT thickness maps are divided into subfields. Any edema that involves the very central subfield would be, by definition, center involved, and if it does not involve the central subfield, but involves the four parafoveal subfields, then it is not center involved (Figure 2).

Figure

Figure 2. OCT images demonstrating center-involved ME with corresponding thickening noted on ILM-RPE thickness map (A). OCT images demonstrating noncenter-involved ME with corresponding thickening noted on ILM-RPE thickness maps (B).

Dr. Dunbar: OCT has certainly changed the paradigm, but there are some estimates that fewer than half of practicing optometrists have the technology in their clinics, which may mean that the classic definition of CSME is still relevant. However, discovering retinal thickening on clinical examination can be technically challenging. Do you have any perspective on what retinal thickening may look like clinically or how to identify it without the benefit of OCT?

Dr. Semes: Use of a very fine beam at the slit lamp in conjunction with a +78.00 D or +60.00 D lens and moving that beam from the disc across to the macula may help in appreciating retinal thickening. Look for distortion or thickening within that beam to see where any portion of the retina might be farther away from the retinal pigment epithelium than the surrounding normal retina.

Dr. Chous: An additional step that may be helpful is to offset the illumination, which essentially creates an optic section through the retinal tissue. An interesting article published in Optometry and Vision Science also showed that any hard exudate within 1,000 μm of the foveal center is highly predictive of CSME diagnosed by seven-field stereo photography.15

Dr. Haynie: Noting the color of the retinal tissue may be helpful. The retina is transparent, and in the absence of thickening, edema, or cystic changes, the retinal vasculature, retinal pigment epithelium, and, sometimes, the choroid are apparent. When there is thickening in the retina, however, whether due to fluid or cystoid edema, the posterior details become less obvious, if they are seen at all.

REFERRAL CRITERIA

Dr. Dunbar: In my view, both center-involved and noncenter-involved ME are clinically significant, although perhaps for different reasons. Center-involved is typically treated more aggressively with pharmacotherapeutics, while there is more of a risk-benefit analysis for patients with noncenter-involved ME in terms of treatment. Those with noncenter-involved ME have to be watched closely for signs of progression, but do they need to be referred promptly or can they be observed by the optometrist?

Dr. Haynie: For providers not using OCT, if they have a patient with ME that meets one of the three criteria for CSME, I think there is an obligation to refer that patient. For those using OCT, if they have a patient with noncenter-involved ME, other factors become important. For example, the compliance of the patient: Is the patient going to come back in 2 months for follow-up? Also, the A1C level and general control of the diabetes, which can be viewed as risk factors—those with a higher risk profile warrant a more prompt referral. For the optometrist in the

community, I do not see a problem with following noncenter-involved ME as long as it is watched closely. Once an increase in ME has been documented, whether it is noncenter-involved ME or not, referral is most likely needed, given that the barrier for initiating treatment is much lower today than compared to historical precedent.

Dr. Chous: I tell patients that the retina is essentially like a sponge, and if it swells up with fluid, the quality of what you can see gets degraded. If a patient needs treatment, I emphasize that we are trying to prevent vision loss. However, vision is not the only guide for initiating treatment—in fact, some in the retina community are more aggressive in treating mild ME in the presence of good vision. My preference is to err on the side of caution and refer early when any risk factors are present, and there are several important ones to be aware of. Obviously, the higher the A1C level, the higher the risk for the disease process to initiate and progress.16-19 Other risk factors include whether the patient has type 1 or type 2 diabetes, as the prevalence of diabetic macular edema (DME) is higher in patients with type 1 disease, although the major burden of disease is among those with type 2 based on sheer numbers of patients.20 The epidemiological evidence suggests that patients with type 1 diabetes have a higher risk for progression to center-involved DME.21 Ethnicity is important, as people of color have a higher risk,22 and a body mass index higher than 30 confers a significantly greater likelihood of developing proliferative disease in patients with type 2 diabetes, according to some reports.23,24 Dyslipidemia, hypertension, and presence of obstructive sleep apnea are other important risk factors.25,26 (See Diabetes: By the Numbers.)

Figure

Dr. Dunbar: Do you have a preferred time frame for when a patient should follow-up with a retina specialist? A couple weeks? Four weeks? Six weeks?

Dr. Ferrucci: I do not think there is a right or wrong answer. Edema from diabetes tends to develop relatively slowly. But there is also no sense in waiting, especially if compliance may be an issue.

Dr. Semes: I try to explain the urgency to the patient using an analogy: Having fluid in the eye is like having a flood in your basement. The longer it is there, the more damage it is going to do. In terms of urgency, if there is an inversion of foveal contour, observed at clinical evaluation or demonstrated on OCT, then I would like to see that patient have the appointment within a 2-week period. This recommendation is consistent with clinical guidelines.

Dr. Dunbar: Obviously, the patient with PDR should be referred, but are there scenarios for referring those with NPDR as well?

Dr. Ferrucci: Yes. One situation I can think of immediately is the patient with NPDR in whom a fluorescein angiogram or a widefield fluorescein angiography shows signs of ischemia. Some retina specialists want to start treatment in that case, and so earlier referral is indicated.

Dr. Haynie: My sense is that retina surgeons are more aggressive with the severe and very severe NPDR cases because they will eventually evolve into proliferative, sight-threatening DR. So why wait until the patient has neovascularization or a vitreous hemorrhage?

Dr. Semes: We also need to acknowledge cost. We are in an age of medicine where there is increasing pressure to protect our health care resources, which in practical terms means finding patients earlier in the disease course so that intervention can be started and evolution of the disease process either slowed or halted. For the patient with diabetic eye disease, it is incumbent on us to find patients earlier so that evolution to proliferative disease that can lead to sight-threatening complications is averted. Referring a patient with advancing or advanced NPDR for potential treatment may be in the patient’s best interest, but it may also be prudent in terms of preventing an outcome that will be more burdensome to the system. This is a lower threat level than center-involving ME, which as we have noted earlier, is a significant vision-threatening finding.

Dr. Dunbar: Who makes the actual appointment for the patient? Do you have your staff do that, or do you hand the patient a card with a name on it and rely on him or her to follow up?

Dr. Semes: We have a staff person make the appointment so that the patient has an appointment time when they leave the clinic.

Dr. Chous: I have my front desk call, and if I am not busy, I will make the call myself. I also like to follow-up with the patient personally to make sure they were seen. I have had many patients with a number of different conditions who did not keep their appointments, so it is good optometric management to follow-up with patients to make sure they kept an appointment, especially if they have a sight-threatening condition.

THE EVOLUTION OF THERAPY FOR CENTER-INVOLVED DME

Dr. Dunbar: To the great benefit of our patients, the treatment paradigm for those with center-involved DME has evolved tremendously. Without question, the gold standard for managing patients with center-involved DME is antivascular endothelial growth factor (anti-VEGF) therapy, of which there are a few options. Having several options within this category is a good problem to have, as patients may experience individualized responses to therapy. In addition, new steroid formulations and delivery mechanisms further expand the treatment possibilities. When it comes time to educate patients, what information do we need to know to communicate effectively?

Dr. Chous: First, we should communicate to our patient the tremendous benefit they can achieve for their visual outcomes by gaining control of their systemic disease. The ACCORD Study showed that patients who gain intensive glycemic and dyslipidemia control have slower progression of DR.27 The American Diabetes Association recommends that patients optimize glycemic and blood pressure to slow progression of retinopathy and that they should know their “ABCs”—meaning, A1C level, blood pressure, and cholesterol levels.28 I recommend anyone managing patients with diabetic eye disease become familiar with the American Diabetes Association’s guidance on screening and treatment. Doctors may also wish to have a general understanding of the types of medications used for diabetes treatment so they can have informed conversations with patients (see Overview of Medications for Treatment of Diabetes).

There is an ever-expanding array of research in diabetic eye disease, which, as you noted, is a good problem. It behooves the optometrist who manages these patients to stay up to date on the published literature, and the recent Protocol T study is a good example. The most important take-away point from this study is that it showed each of the anti-VEGF agents—bevacizumab, aflibercept, and ranibizumab—helped restore vision in the trial participants. However, the finer points of the study changed from year 1 to 2. Overall, after 1 year, patients gained about 13 more letters in the aflibercept group, about 11 letters in the ranibizumab group, and about 10 letters in the bevacizumab group.29

When patients were stratified according to their baseline visual acuity, those who started with 20/50 or worse vision had significantly better vision when they were treated with aflibercept compared to either ranibizumab or bevacizumab. If one had stopped right there, there might be a very different impression about the implications of Protocol T for patient management. As we learned when the year 2 data were published, many of those differences disappeared. There were not statistically significant differences between the three drugs, including patients who were 20/50 or worse at baseline.30 On the other hand, it was apparent that both branded medications outperformed the nonbranded option. In terms of practical application in the clinic, is the extra letter gain on the ETDRS chart with branded versus nonbranded medication enough to justify the additional expense? To me, the answer really is, “it depends.” For the patient with just one eye or for the patient who is just barely legal to drive a car, that extra cost may be entirely justifiable.

Figure

Dr. Ferrucci: A recent analysis showed that aflibercept and ranibizumab are not cost effective relative to bevacizumab for DME unless prices decrease substantially.31 The investigators suggested a price drop of about 60% to 80% before the analysis changed. But even with that in mind, every patient is different. It is possible that patients may not respond to bevacizumab, and there may be extenuating circumstances that would push the treatment decision to a branded option.

Dr. Dunbar: There may be a temptation to correlate the anti-VEGF therapy treatment effects in diabetes with other diseases, such as wet age-related macular degeneration and retinal vein occlusion, but doing so may not be realistic or even practical, because each of these conditions produce varying amounts of VEGF. For example, the CATT study showed almost no difference between ranibizumab and bevacizumab for treatment of age-related macular degeneration, but that was likely because both drugs are powerful enough to suppress the level of VEGF expression in that disease state. In diabetic eye disease and retinal vascular disease, VEGF expression is comparatively higher, and therefore, the greater potency available with ranibizumab or aflibercept may be needed.

As we talk about bringing study data into the real world, we need to consider that the treatment schemas are going to be different. RISE and RIDE employed a monthly schedule, and VIVID and VISTA showed favorable results with dosing every 6 weeks after a loading regimen. But patients can be unpredictable regarding how they attend their clinical appointments, so I think it is fair to ask whether there are scenarios having to do with compliance in which a more potent branded drug may be preferable. Based on my own observations in the clinic, I sense that patients treated with either of the branded medications recover vision a little faster, and the drugs stay on board a little longer, which allows the option to treat and extend. There are fewer injections over a 2- or 3-year period compared with bevacizumab, which we saw in year 2 of Protocol T.

Dr. Haynie: In our practice, a patient newly diagnosed with DME with vision better than 20/50 will receive bevacizumab. If the vision is worse than 20/50, the retina surgeons prefer to use a branded medication—in our clinic, they use aflibercept—for a year or so before switching the patient over to bevacizumab. As Dr. Semes suggested earlier, if the basement is flooded, the sooner you get the water out, the better. For this reason, retina surgeons are very aggressive at the beginning.

Dr. Dunbar: What is the role of steroids in the treatment of patients with DME?

Dr. Haynie: Steroids are playing a larger role in our practice, and if a patient receives three serial injections, 1 month apart, and still has persistent fluid, my surgeons will use either intravitreal triamcinolone acetonide (the preservative-free single dose injection), or they will go with a steroid implant, such as the dexamethasone implant, as an adjunct to treatment.

Dr. Chous: The results of the so-called EARLY Analysis of Diabetic Retinopathy Clinical Research Network (DRCR.net) Protocol I study may be worth mentioning here, which found that if we are not achieving visual acuity gains within the first three injections, then continuing anti-VEGF injections with the same drug is unlikely to provide a benefit.32 Simply put, some patients should be tried on a different anti-VEGF agent earlier, and some just do not respond to anti-VEGF therapy. Another way to look at this is that half of patients with DME do not achieve a good response to anti-VEGF injections,33 and a significant percentage do not have dramatically elevated levels of vitreous VEGF, and so something else may be driving their disease process.34 We have to be aware that sometimes these treatments do not work, and there may be a need to move on to other therapies.

Dr. Ferrucci: What do your surgeons think about using the dexamethasone implant in patients with concurrent glaucoma?

Dr. Haynie: They consider glaucoma to be an absolute contraindication to using the implant.

Dr. Ferrucci: The surgeons I work with have the same mindset. If there is concurrent glaucoma, they will not inject a steroid in the vitreous cavity, even if the patient is a nonresponder to topical drops. Our surgeons are also less aggressive with steroids in the phakic patients versus those who are pseudophakic, knowing the risk for inducing a posterior subcapsular cataract.

Dr. Dunbar: Unfortunately, if you need a steroid because your anti-VEGF drug is not working, it likely means the disease process is pretty well advanced, and there is most likely a poor prognosis in terms of visual outcomes. The good news, however, is that steroids can nevertheless be effective in select patients to achieve at least a modicum of improved vision.

Dr. Semes: This discussion reinforces that while we have guidance from clinical trials, there are a number of options for patients, and these individuals have to be managed on a case-by-case basis.

TREATMENT AND MANAGEMENT DECISIONS FOR PDR

Dr. Dunbar: One of the emerging trends in the treatment of diabetic eye disease is the use of anti-VEGF drugs in patients with DR in the presence of DME.35,36 For those with mild or moderate NPDR, we can look to guidelines from the American Optometric Association37 and the American Academy of Ophthalmology38 for how to manage these patients: annual examination, education about A1C levels, explaining the risk factors, and making sure the endocrinologist or primary care provider is aware of the changes. For severe NPDR, we should be aware of the greater risk for proliferative disease,27,39 hence the need to see these patients every 3 to 4 months.

In addition, the DRCR.net Protocol S study showed that ranibizumab was noninferior to laser in visual acuity change at 2 years for treatment of patients with PDR. However, mean peripheral visual field sensitivity loss was worse, and vitrectomy and DME development were more frequent among patients in the laser group.40 Given that patients with PDR may respond well to PRP with reductions in neovascularization, but the risk of visual field loss and developing poor night vision is high, do intravitreal injections offer an alternate approach?

Dr. Semes: It may depend on the goal of therapy. The goal of PRP is to preserve the macula, but you correctly identified some of the very significant limitations. Number one is going to be reduced visual field, and number two is going to be reduced dark adaptation and vision in limited light settings. There is naturally some give-and-take with the use of laser for PRP that is not necessarily part of the treatment decisions when using anti-VEGF agents.

Dr. Dunbar: And yet the burden of treatment may be an important consideration. In Protocol S, in the ranibizumab group, eyes without DME received a median 10 injections through 2 years, and those with DME received a median 14 injections. In the PRP group, there were 92 eyes that required an additional laser session after a median 7 months, and 72 eyes required ranibizumab for treatment of DME. Even still, there were far fewer clinical visits for treatment in the laser group compared with the ranibizumab group.

Dr. Ferrucci: Patients’ compliance should be an important consideration, as the pharmacotherapy options are only truly effective if patients commit to follow-up. While this is equally true of medical therapy and laser alike, there will likely need to be some criteria that helps to determine which patients will be sufficiently compliant for use of an anti-VEGF agent instead of laser.

Dr. Dunbar: Does anyone foresee a time when anti-VEGF drugs would supplant traditional PRP for PDR? Or will the potential for noncompliance dictate a continuing place for laser in treatment?

Dr. Chous: I think that use of anti-VEGFs could present challenges among this specific patient population. A lot of patients with PDR are coming into the clinic with A1C levels above 9% or 10%, and unfortunately, poor A1C may be a tip-off to poor compliance. There is an argument for using laser in some cases because it may be more protective against terrible outcomes among noncompliant patients. In addition, poor compliance or adherence to therapy may not be totally the patients’ fault. Think of the patient who opts for anti-VEGF instead of laser, but who after one injection decides that the copay is too burdensome. He or she skips the next appointment and return to the clinic 16 months later with a detached retina. How do we best serve patients like that who may fall through the cracks? I have had a few patients in this exact scenario.

I would like to add that some of the secondary outcomes of Protocol S in terms of avoiding night vision loss and loss of visual field speak to quality of vision and quality-of-life issues. Interestingly, I recently heard a presentation by one of the DRCR.net investigators who was involved in Protocol S about unpublished quality-of-vision surveys conducted as part of the study. The investigators found that those in the ranibizumab group were happy with the quality of their vision, but the outcome was not statistically significant compared with the laser group.41 That sort of flies in the face of what we might expect, but then again, what were these patients comparing their vision to if they only received an intravitreal injection and never had laser? As a patient who had multiple rounds of PRP in the mid-1980s and who has experienced significant degradation of scotopic vision, I would certainly opt for anti-VEGF therapy in favor of less laser.

Dr. Ferrucci: The idea that you can potentially save retinal function by doing injections instead of laser is obviously appealing. This was a 2-year study, and I think we need to know what is happening at 5 or 10 years before we really know if intravitreal injection of anti-VEGF drugs for patients with PDR is a viable strategy. I also do not think we can forget cost as an important element in this decision as well, especially as we consider what burden may fall on the patient.

Dr. Chous: If there is concurrent DME and PDR, then anti-VEGF injections make a lot more sense. Both ranibizumab and aflibercept are indicated and approved for treatment of DR in the presence of DME, which may be a clue to how they should be used.

Dr. Dunbar: It is interesting that the rate of vitrectomy was higher in the laser versus ranibizumab group, 15% to 4%. Quality of vision may be difficult to gauge or predict, but if we can prevent the need for patients to go back to the OR, maybe that becomes important.

Dr. Haynie: In our clinic, the decision to go with an intravitreal anti-VEGF for PDR versus PRP depends on how the patient appears at baseline. If a patient has marked capillary nonperfusion and/or large fronds of neovascularization, our surgeons use PRP in conjunction with anti-VEGF injections. Intravitreal injections are used more commonly as monotherapy in those who tend to get diagnosed earlier—patients who might have severe NPDR but only mild neovascularization in the arcade. We have found that those patients can be treated with intravitreal agents and can remain stable for years with an intravitreal injection every 4 to 6 months. We will repeat the fluorescein angiogram 6 months after the anti-VEGF injection to see how things are going, but in most cases, a single intravitreal injection can slow the development of PDR.

Dr. Dunbar: My sense is that there is an emerging interest in trying to get patients back down the ladder a bit: catching the patient with PDR early so that treatment has a chance to get him or her back to NPDR, or intervening when the patient is in the severe NPDR category to try and get him or her to the moderate stage. If you can take that patient with severe symptoms and move him or her back to a moderate or possibly even a mild stage with a periodic injection, that seems like an attractive option and makes you wonder if that may be the future of treating DR.

Dr. Chous: That is a crucial point, but I do not think that should be left to the retina specialist alone, and I think this is where optometrists can be a real asset in this situation. If we are talking about preventing the development of sight-threatening retinopathy, then metabolic control becomes fundamental to achieving that goal. We can and should be counseling patients about the importance of getting blood glucose under control. And the same can be said for sleep apnea, which is an underappreciated risk factor for developing progressive disease. There are estimates that fewer than 30% of those prescribed a sleep apnea device actually use it as recommended.42 We need to educate our patients about this because it obviously increases the risk not only of vision loss but also of dying from a stroke or another cardiovascular cause.

There is also emerging evidence regarding the use of off-label fenofibrate therapy to reduce progression of DR to either DME or PDR.43 This strategy has been approved as first-line therapy for NPDR in adults with type 2 diabetes in Australia. These are all options for our patients and opportunities for us as optometrists to educate patients and the other members of the care team about how we can help to improve the quantity and quality of our patients’ lives.

CONCLUSION

Dr. Dunbar: In some regards, the lessons learned during the ETDRS in the 1980s are still very relevant today. We learned almost 3 decades ago that early treatment could help patients save vision. Today, the advent of anti-VEGF medications has changed the agents used in treatment, but not the fundamental principle of early diagnosis and early intervention. If anything, the optometrist’s role in the modern care of diabetic eye disease is even more important. As a profession, we have the greatest access to patients, and our duty as the primary care providers of eye health presents a mandate to recognize early signs of diabetic eye disease, follow and monitor patients closely when appropriate, and to refer them for treatment when necessary.

  1. National Health and Nutrition Examination Survey 2005-2008, projected to 2012 US population.
  2. Saaddine JB, Honeycutt AA, Narayan KM, et al. Projection of diabetic retinopathy and other major eye diseases among people with diabetes mellitus: United States, 2005–2050. Arch Ophthalmol. 2008;126(12):1740–1747.
  3. BioTrends Research Group. TreatmentTrends®: Diabetic Retinopathy/Diabetic Macular Edema (US) 2013.
  4. Proprietary Quantitative Market Research (n=103 retina specialists, n=23,994 DME eyes with central involvement); fielded November 2013.
  5. Chou CF, et al. Diabetes Care. 2014;37:180-188.
  6. American Academy of Ophthalmology Retina Panel. Preferred Practice Pattern Guidelines: Diabetic Retinopathy. San Francisco, CA, 2014.
  7. Juutilainen A, Lehto S, Rönnemaa T, et al. Retinopathy predicts cardiovascular mortality in type 2 diabetic men and women. Diabetes Care. 2007;30(2):292-299.
  8. American Optometric Association. Evidence-based clinical practice guideline: Eye care of the patient with diabetes mellitus. St. Louis, MO: American Optometric Association, 2014.
  9. Diabetic Retinopathy Study Research Group. Preliminary report on effects of photocoagulation therapy. Am J Ophthalmol. 1976;81:383-96.
  10. Diabetic Retinopathy Study Research Group. Diabetic retinopathy study, report number 6: design, methods, and baseline results. Invest Ophthalmol Vis Sci. 1981;21:149-209.
  11. Diabetic Retinopathy Study Research Group. Photocoagulation treatment of proliferative diabetic retinopathy: the second report of diabetic retinopathy study findings. Ophthalmology. 1978;85:82-106.
  12. Diabetic Retinopathy Study Research Group. Indications for photocoagulation treatment of diabetic retinopathy: Diabetic Retinopathy Study Report no. 14. Int Ophthalmol Clin. 1987;27:239-253.
  13. Ferris FL III, Podgor MJ, Davis MD. Macular edema in Diabetic Retinopathy Study patients; Diabetic Retinopathy Study Report Number 12. Ophthalmology. 1987;94:754-760.
  14. Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study report number 1. Early Treatment Diabetic Retinopathy Study research group. Arch Ophthalmol. 1985;103(12):1796-1806.
  15. Litvin TV, Ozawa GY, Bresnick GH, et al. Utility of hard exudates for the screening of macular edema. Optom Vis Sci. 2014;91(4):370-375.
  16. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulfonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes. Lancet. 1998;352:837-853.
  17. UK Prospective Diabetes Study VIII. Study design, progress, and performance. Diabetologia. 1991;34:877-890.
  18. Davis MD, Fisher MR, Gangnon RE, et al. Risk factors for high-risk proliferative diabetic retinopathy and severe vision loss: Early Treatment Diabetic Retinopathy Study report number 18. Invest Ophthalmol Vis Sci. 1998;39:233-252.
  19. Kilpatrick ES, Rigby AS, Atkin SL, Frier BM. Does severe hypoglycemia influence microvascular complications in type 1 diabetes? An analysis of the Diabetes Control and Complications Trial database. Diabet Med. 2012;29:1195-1198.
  20. Thomas RL, Dunstan FD, Luzio SD, et al. Prevalence of diabetic retinopathy within a national diabetic retinopathy screening service. Br J Ophthalmol. 2015;99(1):64-68.
  21. Zhang X, Saaddine JB, Chou CF, et al. Prevalence of diabetic retinopathy in the United States, 2005-2008. JAMA. 2010;304(6):649-656.
  22. Link CL, McKinlay JB. Disparities in the prevalence of diabetes: is it race/ethnicity or socioeconomic status? Results from the Boston Area Community Health (BACH) Survey. Ethnicity & Disease. 2009;19(3):288-292.
  23. Dirani M, Xie J, Fenwick E, et al. Are obesity and anthropometry risk factors for diabetic retinopathy? The Diabetes Management Project. Invest Ophthalmol Vis Sci. 2011;52(7):4416-4421.
  24. Caštelan S, Tomić M, Gverović Antunica A, et al. Body mass index: a risk factor for retinopathy in type 2 diabetic patients. Mediators Inflamm. 2013;2013:436329.
  25. Mason RH, West SD, Kiire CA, et al. High prevalence of sleep disordered breathing in patients with diabetic macular edema. Retina. 2012;32(9):1791-1798.
  26. Jew OM, Peyman M, Chen TC, Visvaraja S. Risk factors for clinically significant macular edema in a multi-ethnics population with type 2 diabetes. Int J Ophthalmol. 2012;5(4):499-504.
  27. Accord Study Group. Effects of medical therapies on retinopathy progression in type 2 diabetes. N Engl J Med. 2010;363:233-244.
  28. American Diabetes Association. Standards of medical care in diabetes—2015. Diabetes Care. 2015;38(suppl 1):S1-S93.
  29. Wells JA, Glassman AR, et al; Diabetic Retinopathy Clinical Research Network. Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema. N Engl J Med. 2015;372(13):1193-1203.
  30. Wells JA, Glassman AR, Ayala AR, et al. Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema: two-year results from a comparative effectiveness randomized clinical trial. Ophthalmology. 2016;123(6):1351-1359.
  31. Ross EL, Hutton DW, Stein JD, et al; Diabetic Retinopathy Clinical Research Network. Cost-effectiveness of aflibercept, bevacizumab, and ranibizumab for diabetic macular edema treatment: analysis from the Diabetic Retinopathy Clinical Research Network Comparative Effectiveness Trial. JAMA Ophthalmol. 2016;134(8):888-896.
  32. Bressler SB, Qin H, Beck RW, et al; Diabetic Retinopathy Clinical Research Network. Factors associated with changes in visual acuity and OCT Thickness at 1 year after treatment for diabetic macular edema with ranibizumab. Arch Ophthalmol. 2012;30(9):1153-1161.
  33. Singer MA, Kermany DS, Waters J, et al. Diabetic macular edema: it is more than just VEGF. F1000Research. 2016;5:F1000 Faculty Rev-1019.
  34. Kita T, Clermont AC, Murugesan N, et al. Plasma Kallikrein-Kinin System as a VEGF-independent mediator of diabetic macular edema. Diabetes. 2015;64(10):3588-3599.
  35. Ip MS, Domalpally A, Hopkins JJ, et al. Long-term effects of ranibizumab on diabetic retinopathy severity and progression. Arch Ophthalmol. 2012;130(9):1145-1152.
  36. Korobelnik JF, Do DV, Schmidt-Erfurth U, et al. Intravitreal aflibercept for diabetic macular edema. Ophthalmology. 2014;121(11):2247-2254.
  37. American Optometric Association. Evidence-based Clinical Practice Guideline Eye Care of the Patient with Diabetes Mellitus (CPG3). http://aoa.uberflip.com/i/374890-evidence-based-clinical-practice-guideline-diabetes-mellitus. Accessed January 17, 2017.
  38. American Academy of Ophthalmology Retina/Vitreous Panel. Preferred Practice Pattern Guidelines: Diabetic Retinopathy. http://www.aao.org/preferred-practice-pattern/diabetic-retinopathy-ppp-updated-2016. Published February 2014. Accessed August 3, 2016.
  39. Davis MD, Fisher MR, Gangnon RE, et al. Risk factors for high-risk proliferative diabetic retinopathy and severe vision loss: Early Treatment Diabetic Retinopathy Study report number 18. Invest Ophthalmol Vis Sci. 1998;39:233-252.
  40. Gross JG, Glassman AR, Jampol LM, et al; Writing Committee for the Diabetic Retinopathy Clinical Research Network. Panretinal photocoagulation vs intravitreous ranibizumab for proliferative diabetic retinopathy: a randomized clinical trial. JAMA. 2015;314(20):2137-2146.
  41. Beaulieu WT, Bressler NM, Melia M, et al; Diabetic Retinopathy Clinical Research Network. Panretinal photocoagulation versus ranibizumab for proliferative diabetic retinopathy: patient-centered outcomes from a randomized clinical trial. Am J Ophthalmol. 2016;170:206-213.
  42. Weaver TE, Grunstein RR. Adherence to continuous positive airway pressure therapy: the challenge to effective treatment. Proceed Am Thor Soc. 2008;5(2):173-178.
  43. Keech AC, Mitchell P, Summanen PA, et al. Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial. Lancet. 2007;370(9600):1687-1697.
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