Embarking On a New Era in Geographic Atrophy Treatment – Are All Complement Pathways Created Equal?

Embarking On a New Era in Geographic Atrophy Treatment  Are All Complement Pathways Created Equal
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  • Overview

    This panel discussion will examine evolving trial data on functional and anatomic outcomes in geographic atrophy and analyze how targeting different components of the complement pathway may lead to distinct therapeutic outcomes.

    This content was captured during a live-virtual symposium. Polling took place during the symposium.

     

    This activity is supported by an independent medical education grant from Annexon Biosciences.

     

  • Learning Objectives

    Upon completion of this activity, the participant should be able to:

    • Explain the role of the complement pathway in the development and progression of geographic atrophy
    • Discuss the real-world utility of anatomic and functional measures of therapeutic efficacy used in clinical trials for geographic atrophy
    • Evaluate the clinical trial safety and efficacy of commercially available and pipeline therapies that target the complement system
    • Theorize the potential differences and similarities in therapeutic outcomes gained by targeting different components of the complement pathway
  • Accreditation

    Provided by Evolve Medical Education 

    Evolve is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
    Evolve designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

     

  • Participation Method

    In order to obtain credit, proceed through the program, complete the post-test, evaluation and submit for credit.

  • Faculty and Disclosures

    Roger A. Goldberg, MD, MBA

    Roger A. Goldberg, MD, MBA

    Vitreoretinal Specialist

    Bay Area Retina Associates

    Volunteer Faculty

    California Pacific Medical Center

    Walnut Creek, CA

     

    Karl Csaky, MD, PhD

    Karl Csaky, MD, PhD

    Chief Executive Medical Officer 
    Lab Director of the Molecular Ophthalmology Laboratory
    Retina Foundation of the Southwest
    Dallas, TX

     

    Eleonora (Nora) Lad, MD, PhD

    Eleonora (Nora) Lad, MD, PhD

    Vice Chair of Ophthalmology Clinical Research
    Duke University Medical Center
    Durham, NC

     

    DISCLOSURE POLICY
    It is the policy of Evolve that faculty and other individuals who are in the position to control the content of this activity disclose any real or apparent financial relationships relating to the topics of this educational activity. Evolve has full policies in place that will identify and mitigate all financial relationships prior to this educational activity.

    The following faculty/staff members have the following financial relationships with ineligible companies.

    Roger A. Goldberg, MD, MBA, has had a financial relationship or affiliation with the following ineligible companies in the form of Consultant: AbbVie, Annexon Biosciences, Apellis Pharmaceuticals, Boehringer Ingelheim, Carl Zeiss Meditec, Coherus Biosciences, EyePoint Pharmaceuticals, Genentech/Roche, Outlook, and Regeneron. Grant/Research Support: Affamed, Annexon Biosciences, Apellis Pharmaceuticals, Boehringer Ingelheim, Carl Zeiss Meditec, EyePoint Pharmaceuticals, Genentech/Roche, Janssen, Neurotech, and Novo Nordisk. Speaker's Bureau: Apellis Pharmaceuticals, Biogen, and Genentech/Roche.

    Karl Csaky, MD, PhD, has had a financial relationship or affiliation with the following ineligible companies in the form of Consultant: AbbVie, Adverum Biothechnologies, Annexon Biosciences, EyeBio, Genentech, Heidelberg Engineering, Johnson & Johnson Vision, Merck, NGM Biopharmaceuticals, Novartis, Ocular Therapeutix, Regeneron, Ribomic, Roche, and TenPoint Therapeutics. Grant/Research Support: Annexon Biosciences, Genentech, Gyroscope Therapeutics, NGM Biopharmaceuticals, and Novartis. Speaker's Bureau: Genentech.

    Eleonora (Nora) Lad, MD, PhD, has had a financial relationship or affiliation with the following ineligible companies in the form of Consultant: 4DMT, Alexion, Allegro Ophthalmics, Amaros Medical, Annexon Biosciences, Apellis Pharmaceuticals, Aspen Neuroscience, Blue Rock, Boehringer Ingelheim, Broadwing Bio, Galimedix, Gemini Pharmaceuticals, Iveric Bio, Janssen, Nanoscope Therapeutics, NGM Biopharmaceuticals, Novartis, Osanni Bio, Perceive Bio, Retrotope, Roche, Sanofi, and Théa Pharma. Grant/Research Support: Alexion, Apellis Pharmaceuticals, Belite Bio, Boehringer Ingelheim, Gemini Pharmaceuticals, Iveric Bio, Janssen, LumiThera, Neurotech Pharmaceuticals, NGM Biopharmaceuticals, Novartis, and Roche. Shareholder: Amaros Medical, Osanni Bio, and Retrotope. Provisional Patent: 63162741: "A SYSTEM AND METHOD TO PREDICT PROGRESSION OF AGE-RELATED MACULAR DEGENERATION".

    The Evolve staff, planners and peer reviewer have no financial relationships with ineligible companies.

     

  • Disclaimer

    OFF-LABEL STATEMENT
    This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The opinions expressed in the educational activity are those of the faculty. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

    DISCLAIMER
    The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of Evolve or Annexon Biosciences.

    This activity is designed for educational purposes. Participants have a responsibility to utilize this information to enhance their professional development to improve patient outcomes. Conclusions drawn by the participants should be derived from careful consideration of all available scientific information. The participant should use his/her clinical judgment, knowledge, experience, and diagnostic decision-making before applying any information, whether provided here or by others, for any professional use.

  • System Requirements

    • Supported Browsers (2 most recent versions):
      • Google Chrome for Windows, Mac OS, iOS, and Android
      • Apple Safari for Mac OS and iOS
      • Mozilla Firefox for Windows, Mac OS, iOS, and Android
      • Microsoft Edge for Windows
    • Recommended Internet Speed: 5Mbps+

  • Publication Dates

    Release Date:

    Expiration Date:

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